Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review

For many years, vitamin D has been acknowledged for its role in maintaining calcium and phosphate balance. However, recent research assessed immunomodulatory come up with conflicting conclusions. Because the receptor is expressed a variety of immune cell types, study into precise this molecule diseases, notably autoimmune disorders, made possible. The physiologically activated version also promotes tolerogenic immunological condition addition to modulating innate acquired responses. According number studies, important micronutrient plays complex numerous biochemical pathways system disorders that are associated them. Research field still relatively new, some studies claim patients severe illnesses frequently have deficiencies or insufficiencies. This review seeks clarify most on D’s system-related roles, including pathophysiology major disorders.